[CAS NO. 159138-80-4] Cariporide

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PRODUCTS SPECIFICATIONS [159138-80-4]

Catalog

HY-19693

Brand

MCE

CAS

159138-80-4

DESCRIPTION [159138-80-4]

Overview

MDL	MFCD00864683
Molecular Weight	283.35
Molecular Formula	C12H17N3O3S
SMILES	O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Cariporide (HOE-642) is a selective Na ⁺ /H ⁺ exchange inhibitor.

In Vitro

Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na ⁺ and Ca ²⁺ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H ²⁺ O ²⁺ ^[1] . Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca ²⁺ in cardiac myocytes through inhibition of Na ⁺ /H ⁺ exchange ^[2] . Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1) ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intravenous administration of cariporide significantly decreases brain Na ⁺ uptake and reduces cerebral edema, brain swelling, and infarct volume ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 352.92 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5292 mL	17.6460 mL	35.2920 mL
5 mM	0.7058 mL	3.5292 mL	7.0584 mL
10 mM	0.3529 mL	1.7646 mL	3.5292 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzamide, N-(aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-

N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide

Cariporide