[CAS NO. 15985-39-4] L-Methionine-DL-sulfoximine
PRODUCTS SPECIFICATIONS [15985-39-4]
DESCRIPTION [15985-39-4]
Overview
| MDL | MFCD00002621 |
|---|---|
| Molecular Weight | 180.23 |
| Molecular Formula | C5H12N2O3S |
| SMILES | O=C(O)[C@@H](N)CCS(=N)(C)=O |
Summary
L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase . L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 50 mg/mL ( 277.42 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.5485 mL | 27.7423 mL | 55.4847 mL |
| 5 mM | 1.1097 mL | 5.5485 mL | 11.0969 mL |
| 10 mM | 0.5548 mL | 2.7742 mL | 5.5485 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (554.85 mM); Clear solution; Need ultrasonic
References
- [1] Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589.
- [2] Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415.