[CAS NO. 1622921-15-6] Remodelinhydrobromide
PRODUCTS SPECIFICATIONS [1622921-15-6]
DESCRIPTION [1622921-15-6]
Overview
| MDL | MFCD28137688 |
|---|---|
| Molecular Weight | 363.28 |
| Molecular Formula | C15H15BrN4S |
| SMILES | N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br |
3 Publications Citing Use of MCE
Summary
Remodelin, a specific inhibitor of N-acetyltransferase NAT10 , can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10 [1] . NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity [2] .
In Vitro
Remodelin blocks invasion and migration of HCC cells in hypoxic conditions [3]
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Remodelin (100 mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Lmna G609G/G609G mice (HGPS mice) [1] |
| Dosage: | 100 mg/kg |
| Administration: | P.o; daily schedule from 3 weeks of age onward, until the end-point (individual weight maxima) |
| Result: | Well-tolerated by both genotypes, with no weight loss. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 44 mg/mL ( 121.12 mM )
H 2 O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7527 mL | 13.7635 mL | 27.5270 mL |
| 5 mM | 0.5505 mL | 2.7527 mL | 5.5054 mL |
| 10 mM | 0.2753 mL | 1.3763 mL | 2.7527 mL |
References
- [1] Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27.
- [2] Liu H, et al. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. Mol Cell Biochem. 2007;300(1-2):249-258.
- [3] Ma R, et al. Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition. Am J Transl Res. 2016;8(10):4215-4223. Published 2016 Oct 15.