[CAS NO. 1623804-44-3]  Henagliflozin

Henagliflozin (SHR3824) (p.o., 0.1-3.0 mg/kg, once) improves glucose tolerance in a dose-dependent manner in normal mice after exposure to glucose challenge ^[1] .
Henagliflozin (SHR3824) (p.o., 0.3-3.0 mg/kg, once daily, 41 days) increases urinary glucose excretion in a dose-dependent manner and significantly reduces blood glucose levels in GK rats, with no effect on body weight or food intake. The HbA1c values of GK rats treated with 0.3, 1.0 or 3.0 mg/kg are 5.47%, 5.19% and 5.04%, respectively ^[1] .
Henagliflozin (SHR3824) (p.o., 0.3-3.0 mg/kg, once daily, 43 days) causes a dose-dependent increase in urinary output and urinary glucose excretion in db/db mice, with a concomitant decrease in plasma glucose levels and no effect on body weight or food intake. The doses of 0.3, 1.0 or 3.0 mg/kg results in significant reductions in non-fasting and fasting glucose levels of 24.7%, 28.2% or 35.1% and 49.5%, 57.8% or 62.9%, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.