[CAS NO. 1642300-78-4] Eltanexor Z-isomer

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PRODUCTS SPECIFICATIONS [1642300-78-4]

Catalog

HY-100423A

Brand

MCE

CAS

1642300-78-4

DESCRIPTION [1642300-78-4]

Overview

MDL	-
Molecular Weight	428.29
Molecular Formula	C17H10F6N6O
SMILES	O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

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Summary

Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. IC50： In Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC ₅₀ s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively ^[1] . In Vivo:

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 116.74 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3349 mL	11.6743 mL	23.3487 mL
5 mM	0.4670 mL	2.3349 mL	4.6697 mL
10 mM	0.2335 mL	1.1674 mL	2.3349 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (6.42 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αZ)-