[CAS NO. 1644069-80-6] DDR Inhibitor
PRODUCTS SPECIFICATIONS [1644069-80-6]
DESCRIPTION [1644069-80-6]
Overview
| MDL | MFCD31567545 |
|---|---|
| Molecular Weight | 417.44 |
| Molecular Formula | C23H20FN5O2 |
| SMILES | O=C(C1=CN=C2C=CC=CN21)NC3=CC(CNC(NC4=CC=CC(F)=C4)=O)=CC=C3C |
Summary
DDR Inhibitor is a potent discoidin domain receptor (DDR) inhibitor, with an IC 50 of 3.3 nM for DDR2 , and shows 53% inhibition on DDR1 at 1.5 nM.
In Vitro
DDR Inhibitor (Example 6) is a potent DDR inhibitor, with an IC 50 of 3.3 nM for DDR2, and shows 53% inhibition on DDR1 at 1.5 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 65 mg/mL ( 155.71 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3956 mL | 11.9778 mL | 23.9555 mL |
| 5 mM | 0.4791 mL | 2.3956 mL | 4.7911 mL |
| 10 mM | 0.2396 mL | 1.1978 mL | 2.3956 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.17 mg/mL (5.20 mM); Clear solution