[CAS NO. 1644158-57-5] ARN14974
PRODUCTS SPECIFICATIONS [1644158-57-5]
DESCRIPTION [1644158-57-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 404.43 |
| Molecular Formula | C24H21FN2O3 |
| SMILES | O=C(N1C(OC2=CC(C3=CC=C(F)C=C3)=CC=C12)=O)NCCCCC4=CC=CC=C4 |
Summary
ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase ( IC 50 =79 nM) [1] .
In Vitro
ARN14974 (20 μM; 24 hours; SW403 and Raw 264.7 cells) inhibits acid ceramidase (AC) in a complex cellular environment, leading to the intended biochemical response, that is, increased ceramide and decreased sphingosine levels [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney
[1]
.
ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, C
max
, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a C
max
and a half-life time of 628 ng/mL and 72 min, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 123.63 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4726 mL | 12.3631 mL | 24.7262 mL |
| 5 mM | 0.4945 mL | 2.4726 mL | 4.9452 mL |
| 10 mM | 0.2473 mL | 1.2363 mL | 2.4726 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1 mg/mL (2.47 mM); Clear solution