[CAS NO. 16766-30-6] 4-Chloroguaiacol

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PRODUCTS SPECIFICATIONS [16766-30-6]

Catalog

HY-W039169

Brand

MCE

CAS

16766-30-6

DESCRIPTION [16766-30-6]

Overview

MDL	MFCD00070774
Molecular Weight	158.58
Molecular Formula	C7H7ClO2
SMILES	OC1=CC=C(Cl)C=C1OC

For research use only. We do not sell to patients.

Summary

4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MIC s of both 110 μg/mL ^[1] .

IC50 & Target

MIC: 110 μg/mL ( S. aureus ), 110 μg/mL ( E. coli ) ^[1] .

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 630.60 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3060 mL	31.5298 mL	63.0597 mL
5 mM	1.2612 mL	6.3060 mL	12.6119 mL
10 mM	0.6306 mL	3.1530 mL	6.3060 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (15.76 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (15.76 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (15.76 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Patrícia Fontes Pinheiro, et al. Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties. J Agric Food Chem. 2018 Jan 10;66(1):323-330.