[CAS NO. 1677668-27-7] GNE-6468

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1677668-27-7]

Catalog

HY-19775

Brand

MCE

CAS

1677668-27-7

DESCRIPTION [1677668-27-7]

Overview

MDL	-
Molecular Weight	433.84
Molecular Formula	C23H16ClN3O4
SMILES	OC1=CC(C2=C3N(C(C(C4=C(C5CC5)C=CC=C4Cl)=O)=N2)C=CC=N3)=CC=C1C(O)=O

For research use only. We do not sell to patients.

Summary

GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC ₅₀ value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC ₅₀ of 30 nM for IL-17 PBMC ^[1] .

IC50 & Target

ROR-γ

2 nM (EC ₅₀ )

In Vivo

GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CL _hep = 17 and 42 mL/min/kg, respectively) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 11.52 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3050 mL	11.5250 mL	23.0500 mL
5 mM	0.4610 mL	2.3050 mL	4.6100 mL
10 mM	0.2305 mL	1.1525 mL	2.3050 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.