[CAS NO. 1687736-54-4] SGC707
PRODUCTS SPECIFICATIONS [1687736-54-4]
DESCRIPTION [1687736-54-4]
Overview
| MDL | MFCD28411624 |
|---|---|
| Molecular Weight | 298.34 |
| Molecular Formula | C16H18N4O2 |
| SMILES | O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2 |
5 Publications Citing Use of MCE
Summary
SGC707 is a potent, selective, and non-competitive PRMT3 ( protein arginine methyltransferase 3 ) inhibitor ( IC 50 =31 nM, K d =53 nM).
IC50 & Target
|
PRMT3 31 nM (IC 50 ) |
In Vitro
SGC707 (0-10 μM; 6 h) binds to PRMT3 in both HEK293 and A549 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | HEK293 and A549 cells |
| Concentration: | 0-10 μM |
| Incubation Time: | 6 hours |
| Result: | Stabilized PRMT3 in both HEK293 and A549 cells with EC 50 values of 1.3 μM and 1.6 μM, respectively. |
In Vivo
SGC707 (intraperitoneal injection; 10 mg/kg; 3 times per week; 3 w) treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Western-type diet-fed LDL (lipoprotein) receptor knockout mice [2] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks |
| Result: | Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 335.19 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3519 mL | 16.7594 mL | 33.5188 mL |
| 5 mM | 0.6704 mL | 3.3519 mL | 6.7038 mL |
| 10 mM | 0.3352 mL | 1.6759 mL | 3.3519 mL |
References
- [1] Kaniskan HÜ, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70.
- [2] de Jong LM, et al. PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. Sci Rep. 2022 Jan 10;12(1):483.