[CAS NO. 1699720-85-8] (S)-ML753286
PRODUCTS SPECIFICATIONS [1699720-85-8]
DESCRIPTION [1699720-85-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 355.43 |
| Molecular Formula | C20H25N3O3 |
| SMILES | COC1=CC=C2C(NC3=C2C[C@]4([H])N(C([C@H](C)NC4=O)=O)[C@H]3CC(C)C)=C1 |
Summary
IC50 & Target
IC50: 0.6 μM (BCRP efflux transporter) [1]
In Vivo
(S)-ML753286 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t 1/2 s of 0.9 h and 2.0 h for 2 mg/kg (iv) and 20 mg/kg (po) in rats, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 140.67 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8135 mL | 14.0675 mL | 28.1349 mL |
| 5 mM | 0.5627 mL | 2.8135 mL | 5.6270 mL |
| 10 mM | 0.2813 mL | 1.4067 mL | 2.8135 mL |