[CAS NO. 1699720-89-2] ML753286
PRODUCTS SPECIFICATIONS [1699720-89-2]
DESCRIPTION [1699720-89-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 355.43 |
| Molecular Formula | C20H25N3O3 |
| SMILES | COC1=CC=C2C(NC3=C2C[C@]4(N([C@H]3CC(C)C)C([C@@H](NC4=O)C)=O)[H])=C1 |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 0.6 μM (BCRP) [1]
In Vitro
ML753286 has IC 50 values of >30, 0.6, and 39.0 μM for the inhibition of P-gp-, BCRP-, and OATP mediated transport, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
ML753286 (25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV); 0.083-24 hours) appears to completely inhibit Bcrp functions in rats at 25 mg/kg PO or at 20 mg/kg IV. The t max values in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Bcrp KO (Abcg2−/−) and WT (Wistar) Rats [1] |
| Dosage: | 25- or 50-mg/kg (PO); 10 or 20 mg/kg (IV) (Pharmacokinetic Study) |
| Administration: | PO or IV; 0.083, 0.25, 0.5, 1, 2, 4, 6, 8, and 24 hours |
| Result: | The t max values in plasma were 1.4, 4.0, and 4.1 hours in Bcrp KO rats, WT rats pre-administered 25-mg/kg ML753286, and WT rats pre-administered 50-mg/kg ML753286, respectively. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |