[CAS NO. 171964-73-1] ZD-0892

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PRODUCTS SPECIFICATIONS [171964-73-1]

Catalog

HY-19254

Brand

MCE

CAS

171964-73-1

DESCRIPTION [171964-73-1]

Overview

MDL	-
Molecular Weight	499.52
Molecular Formula	C24H32F3N3O5
SMILES	CC(C)[C@@H](C(N1[C@H](C(N[C@H](C(C(F)(F)F)=O)C(C)C)=O)CCC1)=O)NC(C2=CC=C(OC)C=C2)=O

For research use only. We do not sell to patients.

Summary

ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K _i s of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase , respectively.

IC50 & Target

Ki: 6.7 nM (Human neutrophil elastase), 200 nM (Human neutrophil elastase) ^[1]

In Vivo

ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis ^[1] . ZD-0892 can reverse advanced pulmonary vascular disease produced in rats ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 500.48 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0019 mL	10.0096 mL	20.0192 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

* All of the co-solvents are available by MCE.