[CAS NO. 17290-70-9] Isosinensetin
PRODUCTS SPECIFICATIONS [17290-70-9]
DESCRIPTION [17290-70-9]
Overview
| MDL | MFCD21333406 |
|---|---|
| Molecular Weight | 372.37 |
| Molecular Formula | C20H20O7 |
| SMILES | O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=CC(OC)=C13 |
Summary
Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on P-glycoprotein (P-gp) in MDR1-MDCKII cells [1] [2] .
IC50 & Target
P-glycoprotein [2]
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 12.5 mg/mL ( 33.57 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6855 mL | 13.4275 mL | 26.8550 mL |
| 5 mM | 0.5371 mL | 2.6855 mL | 5.3710 mL |
| 10 mM | 0.2686 mL | 1.3428 mL | 2.6855 mL |
References
- [1] Wang D, et al. Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. J Pharm Biomed Anal. 2007 May 9;44(1):63-9.
- [2] Bai J, et al. Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. Toxicol Appl Pharmacol. 2019 Apr 15;369:49-59.
- [3] Kanda Panthong, et al. Prenylated flavone from roots of a hybrid between Artocarpus heterophyllus and Artocarpus integer and its biological activities. Journal of the Brazilian Chemical Society. Print version ISSN 0103-5053
Synonyms