[CAS NO. 173932-75-7] Gambogenic acid

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [173932-75-7]

Catalog

HY-N5024

Brand

MCE

CAS

173932-75-7

DESCRIPTION [173932-75-7]

Overview

MDL	-
Molecular Weight	630.77
Molecular Formula	C38H46O8
SMILES	O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@]([C@]31OC4=C5C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C4C/C=C(C)\C)([H])C[C@@]2([H])C=C3C5=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Phytomedicine. 11 August 2022, 154390.

Summary

Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2 , specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination ^[1] .

IC50 & Target

EZH2

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 396.34 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5854 mL	7.9268 mL	15.8536 mL
5 mM	0.3171 mL	1.5854 mL	3.1707 mL
10 mM	0.1585 mL	0.7927 mL	1.5854 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 4 mg/mL (6.34 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260.