Sign in to enjoy up to 20% OFF or Register
  •  
[email protected]
Chemistry
Bioactive Molecules
Natural Products
ADCs
Antibodies
Multiplex IHC
Material Science
Others
+1 800-931-7508 [email protected]
Sign in to enjoy up to 20% OFF

[CAS NO. 175865-59-5]  Valganciclovirhydrochloride

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [175865-59-5]

Catalog
HY-A0032A
Brand
MCE
CAS
175865-59-5

DESCRIPTION [175865-59-5]

Overview

MDLMFCD08460118
Molecular Weight390.82
Molecular FormulaC14H23ClN6O5
SMILESN[C@@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O.[H]Cl

For research use only. We do not sell to patients.

Summary

Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections. IC50 Value: Target: CMV in vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases [1]. in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) [3].


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00031434 National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections
July 2002 Phase 1|Phase 2
NCT00017784 Hoffmann-La Roche|NIH AIDS Clinical Trials Information Service
Cytomegalovirus Retinitis|HIV Infections
Phase 3
NCT00006145 National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections|HIV Infections
August 2000 Phase 3

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 127.94 mM ; Need ultrasonic)

H 2 O : ≥ 50 mg/mL ( 127.94 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5587 mL 12.7936 mL 25.5872 mL
5 mM 0.5117 mL 2.5587 mL 5.1174 mL
10 mM 0.2559 mL 1.2794 mL 2.5587 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (255.87 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 4.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, hydrochloride (1:1)
L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride
RS 079070-194
Valganciclovir hydrochloride
Ro 107-9070/194
Valcyte

Information
Shipping
Privacy notice
Terms of Service
About us
Contact us
Customer services
Search
Custom Synthesis
My account
My account
Orders
Addresses
Shopping cart
Pay
Powered by Arctom Copyright © 2025 Arctom. All rights reserved.