[CAS NO. 17676-33-4] Neoruscogenin

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PRODUCTS SPECIFICATIONS [17676-33-4]

Catalog

HY-N2253

Brand

MCE

CAS

17676-33-4

DESCRIPTION [17676-33-4]

Overview

MDL	-
Molecular Weight	428.60
Molecular Formula	C27H40O4
SMILES	C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]3(OC4)CCC4=C)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2

For research use only. We do not sell to patients.

Summary

Neoruscogenin, a member of the steroidal sapogenin family, is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1) ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 116.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3332 mL	11.6659 mL	23.3318 mL
5 mM	0.4666 mL	2.3332 mL	4.6664 mL
10 mM	0.2333 mL	1.1666 mL	2.3332 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.83 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.56 mg/mL (1.31 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.56 mg/mL (1.31 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Helleboid S, et al. The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).J Biomol Screen. 2014 Mar;19(3):399-406.

Synonyms

Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-

Spirosta-5,25(27)-diene-1β,3β-diol

Neoruscogenin

(1β,3β)-Spirosta-5,25(27)-diene-1,3-diol

25(27)-Dehydroruscogenin