[CAS NO. 1769-24-0] 2-Methylquinazolin-4-ol
PRODUCTS SPECIFICATIONS [1769-24-0]
DESCRIPTION [1769-24-0]
Overview
| MDL | MFCD05270928 |
|---|---|
| Molecular Weight | 160.17 |
| Molecular Formula | C9H8N2O |
| SMILES | O=C1NC(C)=NC2=C1C=CC=C2 |
Summary
In Vitro
2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Mice [2] |
| Dosage: | 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg |
| Administration: | Oral gavage, for two days |
| Result: | Showed an inhibitory effect upon ATCase. |
Appearance
Solid
Source
Bacillus cereus
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 312.17 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.2434 mL | 31.2168 mL | 62.4337 mL |
| 5 mM | 1.2487 mL | 6.2434 mL | 12.4867 mL |
| 10 mM | 0.6243 mL | 3.1217 mL | 6.2434 mL |
References
- [1] S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2.
- [2] Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.
Synonyms