[CAS NO. 1776055-05-0] ML230
PRODUCTS SPECIFICATIONS [1776055-05-0]
DESCRIPTION [1776055-05-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 439.47 |
| Molecular Formula | C25H21N5O3 |
| SMILES | O=C(C1=COC=C1)N2CCN(C3=CC(C4=CC=CO4)=NC5=CC(C6=CC=CC=C6)=NN53)CC2 |
Summary
ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1] .
IC50 & Target
EC50: ABCG2 (0.13 μM) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 75.84 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2755 mL | 11.3773 mL | 22.7547 mL |
| 5 mM | 0.4551 mL | 2.2755 mL | 4.5509 mL |
| 10 mM | 0.2275 mL | 1.1377 mL | 2.2755 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.69 mM); Clear solution