[CAS NO. 178946-89-9] C-DIM12
PRODUCTS SPECIFICATIONS [178946-89-9]
DESCRIPTION [178946-89-9]
Overview
| MDL | MFCD05625919 |
|---|---|
| Molecular Weight | 356.85 |
| Molecular Formula | C23H17ClN2 |
| SMILES | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
1 Publications Citing Use of MCE
Summary
C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons. Target: Nurr1 in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 280.23 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8023 mL | 14.0115 mL | 28.0230 mL |
| 5 mM | 0.5605 mL | 2.8023 mL | 5.6046 mL |
| 10 mM | 0.2802 mL | 1.4011 mL | 2.8023 mL |
References
- [1] De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub
- [2] Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.