[CAS NO. 17910-09-7] Curzerene
PRODUCTS SPECIFICATIONS [17910-09-7]
DESCRIPTION [17910-09-7]
Overview
| MDL | MFCD23379925 |
|---|---|
| Molecular Weight | 216.32 |
| Molecular Formula | C15H20O |
| SMILES | C=C([C@H]([C@@](C)(C=C)C1)CC2=C1OC=C2C)C |
Summary
IC50 & Target
GSTA1 [1]
In Vitro
Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC
50
to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively
[1]
.
Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells
[1]
.
Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose
[1]
.
Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells
[1]
.
Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. |
Apoptosis Analysis [1]
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis of the cells in a dose-dependent manner. |
Apoptosis Analysis [1]
| Cell Line: | SPC-A1 cells |
| Concentration: | 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Induced G2/M cell cycle arrest of SPC A1 cells. |
RT-PCR [1]
| Cell Line: | SPC-A1 cells |
| Concentration: | 6.25 µM, 25 µM, 100 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased GSTA1 mRNA expression. |
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 250 mg/mL ( 1155.70 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6228 mL | 23.1139 mL | 46.2278 mL |
| 5 mM | 0.9246 mL | 4.6228 mL | 9.2456 mL |
| 10 mM | 0.4623 mL | 2.3114 mL | 4.6228 mL |
Synonyms