[CAS NO. 1796565-52-0] Orexin2ReceptorAgonist
PRODUCTS SPECIFICATIONS [1796565-52-0]
DESCRIPTION [1796565-52-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 586.70 |
| Molecular Formula | C32H34N4O5S |
| SMILES | O=C(C1=CC=CC(C)=C1)NCCNC2=CC(NS(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)(=O)=O)=CC=C2 |
Summary
Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist. IC50 value: 23 nM (EC50) Target: Orexin 2 Receptor Orexin 2 Receptor Agonist shows not only potent activity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 32 mg/mL ( 54.54 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7044 mL | 8.5222 mL | 17.0445 mL |
| 5 mM | 0.3409 mL | 1.7044 mL | 3.4089 mL |
| 10 mM | 0.1704 mL | 0.8522 mL | 1.7044 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution