[CAS NO. 1801856-93-8] KL044
PRODUCTS SPECIFICATIONS [1801856-93-8]
DESCRIPTION [1801856-93-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 359.81 |
| Molecular Formula | C21H14ClN3O |
| SMILES | O=C(CN1C2=C(C=CC=C2)C3=C1C=CC=C3)NC4=C(C=CC=C4Cl)C#N |
Summary
KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC 50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity [1] .
IC50 & Target
pEC50: 7.32 [1]
In Vitro
KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 277.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7792 mL | 13.8962 mL | 27.7924 mL |
| 5 mM | 0.5558 mL | 2.7792 mL | 5.5585 mL |
| 10 mM | 0.2779 mL | 1.3896 mL | 2.7792 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.95 mM); Clear solution