[CAS NO. 1804915-68-1] WCK-4234

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PRODUCTS SPECIFICATIONS [1804915-68-1]

Catalog

HY-125604

Brand

MCE

CAS

1804915-68-1

DESCRIPTION [1804915-68-1]

Overview

MDL	-
Molecular Weight	269.21
Molecular Formula	C7H8N3NaO5S
SMILES	O=S(ON1[C@@H]2CC[C@@H](C#N)[N@@](C2)C1=O)(O[Na])=O

For research use only. We do not sell to patients.

Summary

WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 371.46 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7146 mL	18.5729 mL	37.1457 mL
5 mM	0.7429 mL	3.7146 mL	7.4291 mL
10 mM	0.3715 mL	1.8573 mL	3.7146 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.29 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.29 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.29 mM); Clear solution

* All of the co-solvents are available by MCE.