[CAS NO. 183506-66-3] Apicidin

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PRODUCTS SPECIFICATIONS [183506-66-3]

Catalog

HY-N6735

Brand

MCE

CAS

183506-66-3

DESCRIPTION [183506-66-3]

Overview

MDL	MFCD03452661
Molecular Weight	623.78
Molecular Formula	C34H49N5O6
SMILES	O=C(NC(C(N1[C@]2([H])CCCC1)=O)[C@@H](C)CC)[C@@H](NC([C@@H](NC2=O)CCCCCC(CC)=O)=O)CC3=CN(OC)C4=C3C=CC=C4

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Summary

Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity ^[1] .

IC50 & Target

HDAC ^[1]

Appearance

Solid

Source

Toxic Fusarium

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 40.08 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6031 mL	8.0156 mL	16.0313 mL
5 mM	0.3206 mL	1.6031 mL	3.2063 mL
10 mM	0.1603 mL	0.8016 mL	1.6031 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.