[CAS NO. 183619-38-7] CPI-1189

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PRODUCTS SPECIFICATIONS [183619-38-7]

Catalog

HY-100376

Brand

MCE

CAS

183619-38-7

DESCRIPTION [183619-38-7]

Overview

MDL	MFCD00774476
Molecular Weight	234.29
Molecular Formula	C13H18N2O2
SMILES	O=C(NC(C)(C)C)C1=CC=C(NC(C)=O)C=C1

For research use only. We do not sell to patients.

Summary

CPI-1189 is a TNF-α release inhibitor with antioxidant and neuroprotective properties. CPI-1189 is used for researches of HIV-associated neurotoxicity and thus is a candidate for neuroprotective therapy in humans suffered from HIV-associated CNS disease ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00002414	Centaur Pharmaceuticals\|NIH AIDS Clinical Trials Information Service	HIV Infections		Phase 2
NCT00002209	Centaur Pharmaceuticals\|NIH AIDS Clinical Trials Information Service	AIDS Dementia Complex\|HIV Infections		Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 426.82 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2682 mL	21.3411 mL	42.6821 mL
5 mM	0.8536 mL	4.2682 mL	8.5364 mL
10 mM	0.4268 mL	2.1341 mL	4.2682 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

* All of the co-solvents are available by MCE.