[CAS NO. 183945-55-3] PfDHODH-IN-1
PRODUCTS SPECIFICATIONS [183945-55-3]
DESCRIPTION [183945-55-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 296.24 |
| Molecular Formula | C14H11F3N2O2 |
| SMILES | O=C(NC1=CC=C(C(F)(F)F)C=C1)/C(C#N)=C(C2CC2)\O |
Summary
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 168.78 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3756 mL | 16.8782 mL | 33.7564 mL |
| 5 mM | 0.6751 mL | 3.3756 mL | 6.7513 mL |
| 10 mM | 0.3376 mL | 1.6878 mL | 3.3756 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.44 mM); Clear solution
References
- [1] Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.
- [2] Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.