[CAS NO. 18474-59-4] eIF4A3-IN-8

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PRODUCTS SPECIFICATIONS [18474-59-4]

Catalog

HY-33838

Brand

MCE

CAS

18474-59-4

DESCRIPTION [18474-59-4]

Overview

MDL	MFCD02664477
Molecular Weight	175.18
Molecular Formula	C10H9NO2
SMILES	O=C(C(N1)=CC2=C1C=C(C)C=C2)O

For research use only. We do not sell to patients.

Summary

eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 ( eIF4A3 ) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 570.84 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7084 mL	28.5421 mL	57.0841 mL
5 mM	1.1417 mL	5.7084 mL	11.4168 mL
10 mM	0.5708 mL	2.8542 mL	5.7084 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (14.27 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (14.27 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (14.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.