[CAS NO. 187870-78-6] Rimeporide

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PRODUCTS SPECIFICATIONS [187870-78-6]

Catalog

HY-19273

Brand

MCE

CAS

187870-78-6

DESCRIPTION [187870-78-6]

Overview

MDL	MFCD30533663
Molecular Weight	333.38
Molecular Formula	C11H15N3O5S2
SMILES	O=C(NC(N)=N)C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C

For research use only. We do not sell to patients.

Summary

Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺ /H ⁺ exchanger (NHE-1).

IC50 & Target

NHE1 ^[1]

In Vitro

Blocking NHE-1 activity has been shown to decrease intracellular Na ⁺ and Ca ²⁺ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02710591	EspeRare Foundation	Muscular Dystrophy, Duchenne	March 2016	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL ( 59.99 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9996 mL	14.9979 mL	29.9958 mL
5 mM	0.5999 mL	2.9996 mL	5.9992 mL
10 mM	0.3000 mL	1.4998 mL	2.9996 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Benzamide, N-(aminoiminomethyl)-2-methyl-4,5-bis(methylsulfonyl)-

N-(Aminoiminomethyl)-2-methyl-4,5-bis(methylsulfonyl)benzamide

Rimeporide