[CAS NO. 1896-62-4] trans-Benzylideneacetone

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PRODUCTS SPECIFICATIONS [1896-62-4]

Catalog

HY-W012595A

Brand

MCE

CAS

1896-62-4

DESCRIPTION [1896-62-4]

Overview

MDL	MFCD00008779
Molecular Weight	146.19
Molecular Formula	C10H10O
SMILES	CC(/C=C/C1=CC=CC=C1)=O.[E]

For research use only. We do not sell to patients.

Summary

trans-Benzylideneacetone (trans-Benzalacetone), a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila , is an enzyme inhibitor against phospholipase A2 (PLA2) . trans-Benzylideneacetone is an immunosuppressant ^[1] .

IC50 & Target

PLA2

In Vitro

Benzylideneacetone (trans-Benzylideneacetone; 0.005, 0.05, 0.5, 5, 50, 500, 5000 μM) inhibits hemocytespreading behavior of hemocytes of S. exigua larvae. Benzylideneacetone enhances virulence of Bacillus thuringiensisagainst beet armyworm ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

<39°C Solid,>42°C Liquid

Source

a metabolite of gram-negative entomopathogenic bacterium Xenorhabdus nematophila

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 684.04 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.8404 mL	34.2021 mL	68.4041 mL
5 mM	1.3681 mL	6.8404 mL	13.6808 mL
10 mM	0.6840 mL	3.4202 mL	6.8404 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (17.10 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kwon B, et al. Benzylideneacetone, an immunosuppressant, enhances virulence of Bacillus thuringiensisagainst beet armyworm (Lepidoptera: Noctuidae). J Econ Entomol. 2008 Feb;101(1):36-41.

Synonyms

3-Buten-2-one, 4-phenyl-, (3E)-

3-Buten-2-one, 4-phenyl-, (E)-

(3E)-4-Phenyl-3-buten-2-one

Methyl trans-styryl ketone

trans-Benzylideneacetone

trans-1-Phenylbut-1-en-3-one

trans-Benzalacetone

trans-4-Phenyl-3-buten-2-one

trans-Phenylvinyl methyl ketone

(E)-Benzylideneacetone

(E)-Methyl styryl ketone

(E)-Benzalacetone

(E)-4-Phenyl-3-buten-2-one

Methyl (E)-2-phenylethenyl ketone

trans-4-Phenyl-3-butene-2-one

trans-4-Phenylbuten-2-one

(E)-Benzalacetone