[CAS NO. 193275-86-4] (Rac)-Lonafarnib

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PRODUCTS SPECIFICATIONS [193275-86-4]

Catalog

HY-15136B

Brand

MCE

CAS

193275-86-4

DESCRIPTION [193275-86-4]

Overview

MDL	-
Molecular Weight	638.82
Molecular Formula	C27H31Br2ClN4O2
SMILES	O=C(N1CCC(CC(N2CCC(C3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N

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Summary

(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras , K-ras and N-ras with IC ₅₀ values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities ^[1] .

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References

[1] Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56.