[CAS NO. 193681-12-8] Alamifovir

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PRODUCTS SPECIFICATIONS [193681-12-8]

Catalog

HY-119691

Brand

MCE

CAS

193681-12-8

DESCRIPTION [193681-12-8]

Overview

MDL	-
Molecular Weight	575.42
Molecular Formula	C19H20F6N5O5PS
SMILES	COC1=CC=C(C=C1)SC2=C3N=CN(C3=NC(N)=N2)CCOCP(OCC(F)(F)F)(OCC(F)(F)F)=O

For research use only. We do not sell to patients.

Summary

Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV) . Alamifovir has high activity against HBV replication and sustained antiviral effect ^[1] ^[2] .

In Vitro

MCC-478 (0-10 μM) has EC ₅₀ s of 0.027 μM for wild-type HBV, 2.6 μM for M552I, 3.3 μM for M552V, and 2.0 μM for L528M/M552V ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.