[CAS NO. 1943733-16-1] YU238259
PRODUCTS SPECIFICATIONS [1943733-16-1]
DESCRIPTION [1943733-16-1]
Overview
| MDL | MFCD30532769 |
|---|---|
| Molecular Weight | 459.95 |
| Molecular Formula | C22H22ClN3O4S |
| SMILES | COC1=CC=C(S(NCC2=CC=C(C(NCCC3=CC=C(Cl)C=N3)=O)C=C2)(=O)=O)C=C1 |
Summary
YU238259 is an inhibitor of homology-dependent DNA repair ( HDR ), used for cancer research.
IC50 & Target
HDR [1]
In Vitro
YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD 50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 110 mg/mL ( 239.16 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1741 mL | 10.8707 mL | 21.7415 mL |
| 5 mM | 0.4348 mL | 2.1741 mL | 4.3483 mL |
| 10 mM | 0.2174 mL | 1.0871 mL | 2.1741 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.75 mg/mL (5.98 mM); Clear solution