[CAS NO. 1945950-20-8] PDD00017272

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PRODUCTS SPECIFICATIONS [1945950-20-8]

Catalog

HY-133531

Brand

MCE

CAS

1945950-20-8

DESCRIPTION [1945950-20-8]

Overview

MDL	-
Molecular Weight	531.67
Molecular Formula	C23H25N5O4S3
SMILES	O=S(C1=CC2=C(N(CC3=C(C)N=C(C)S3)C(N(CC4=CN=C(C)S4)C2=O)=O)C=C1)(NC5(C)CC5)=O

For research use only. We do not sell to patients.

Summary

PDD00017272 (34f) is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) , with EC ₅₀ of 4.8 nM and 9.2 nM in biochemical assay and cell POM, respectively ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 25 mg/mL ( 47.02 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8809 mL	9.4043 mL	18.8087 mL
5 mM	0.3762 mL	1.8809 mL	3.7617 mL
10 mM	0.1881 mL	0.9404 mL	1.8809 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (1.88 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Bohdan Waszkowycz, et al. Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. J Med Chem. 2018 Dec 13;61(23):10767-10792.