[CAS NO. 195199-95-2] SB 258719

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PRODUCTS SPECIFICATIONS [195199-95-2]

Catalog

HY-U00443

Brand

MCE

CAS

195199-95-2

DESCRIPTION [195199-95-2]

Overview

MDL	-
Molecular Weight	338.51
Molecular Formula	C18H30N2O2S
SMILES	O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O

For research use only. We do not sell to patients.

Summary

SB 258719 is a selective 5-HT ₇ receptor antagonist with high affinity ( pK _i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease ^[1] ^[2] ^[3] .

IC50 & Target

5-HT ₇ Receptor

7.5 (pKi)

In Vitro

SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss Webster mice (20-25 g) ^[2] .
Dosage:	5-20 mg/kg
Administration:	I.p.
Result:	Significantly attenuated the 5-CT-induced hypothermia.

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 738.53 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9541 mL	14.7706 mL	29.5412 mL
5 mM	0.5908 mL	2.9541 mL	5.9082 mL
10 mM	0.2954 mL	1.4771 mL	2.9541 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 6.25 mg/mL (18.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzenesulfonamide, N,3-dimethyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-

Benzenesulfonamide, N,3-dimethyl-N-[1-methyl-3-(4-methyl-1-piperidinyl)propyl]-, (R)-

N,3-Dimethyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]benzenesulfonamide

SB 258719