[CAS NO. 1952247-05-0]  PDD00017238

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PRODUCTS SPECIFICATIONS [1952247-05-0]

Catalog
HY-133530
Brand
MCE
CAS
1952247-05-0

DESCRIPTION [1952247-05-0]

Overview

MDL-
Molecular Weight476.60
Molecular FormulaC19H20N6O3S3
SMILESO=S(C1=CC=C(N2CC3=C(C)N=C(C)S3)C(N(C4=NC=NS4)C2=O)=C1)(NC5(C)CC5)=O

For research use only. We do not sell to patients.

Summary

PDD00017238 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) , with EC 50 values of 40 nM and 55 nM in biochemical assay and cell POM, respectively [1] .


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 104.91 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0982 mL 10.4910 mL 20.9820 mL
5 mM 0.4196 mL 2.0982 mL 4.1964 mL
10 mM 0.2098 mL 1.0491 mL 2.0982 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution

* All of the co-solvents are available by MCE.