[CAS NO. 200006-08-2] ALX-5407 hydrochloride

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PRODUCTS SPECIFICATIONS [200006-08-2]

Catalog

HY-10711A

Brand

MCE

CAS

200006-08-2

DESCRIPTION [200006-08-2]

Overview

MDL	-
Molecular Weight	429.91
Molecular Formula	C24H25ClFNO3
SMILES	FC1=CC=C([C@H](OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1.[H]Cl

For research use only. We do not sell to patients.

Summary

ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC ₅₀ value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia ^[1] .

In Vitro

ALX-5407 hydrochloride (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [ ³ H]glycine uptake in rat brain and QT6-1C cells with an IC ₅₀ value of 3 nM ^[1] .
ALX-5407 hydrochloride (50 nM) shows slow dissociation kinetics in QT6-1C cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ALX-5407 hydrochloride (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

[1] Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.