[CAS NO. 20137-37-5] Rotundic acid

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PRODUCTS SPECIFICATIONS [20137-37-5]

Catalog

HY-N2217

Brand

MCE

CAS

20137-37-5

DESCRIPTION [20137-37-5]

Overview

MDL	-
Molecular Weight	488.70
Molecular Formula	C30H48O5
SMILES	C[C@@]1(CO)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

For research use only. We do not sell to patients.

Summary

Rotundic acid, a triterpenoid obtained from Ilex rotunda Thunb. , induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities ^[1] .

IC50 & Target

mTOR

p38 MAPK

Appearance

Solid

Source

I. rotunda

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 204.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0462 mL	10.2312 mL	20.4625 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.12 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.12 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545.

Synonyms

Urs-12-en-28-oic acid, 3,19,23-trihydroxy-, (3β,4α)-

Urs-12-en-28-oic acid, 3β,19,23-trihydroxy-

(3β,4α)-3,19,23-Trihydroxyurs-12-en-28-oic acid

Rotundic acid

3β,19α,23-Trihydroxyurs-12-en-28-oic acid

22-Deoxyilexolic acid A