[CAS NO. 2070015-13-1] ML241hydrochloride
PRODUCTS SPECIFICATIONS [2070015-13-1]
DESCRIPTION [2070015-13-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 408.92 |
| Molecular Formula | C23H25ClN4O |
| SMILES | Cl[H].C1(N2C3=CC=CC=C3OCC2)=NC(NCC4=CC=CC=C4)=C5CCCCC5=N1 |
Summary
IC50 & Target
IC50: 100 nM (p97) [1]
In Vitro
ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K i values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub G76V -GFP with IC 50 of 3.5 μM [1] . ML241 is cytotoxic to HCT15 and SW403 cells, with GI 50 s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 34 mg/mL ( 83.15 mM )
H 2 O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4455 mL | 12.2273 mL | 24.4547 mL |
| 5 mM | 0.4891 mL | 2.4455 mL | 4.8909 mL |
| 10 mM | 0.2445 mL | 1.2227 mL | 2.4455 mL |
References
- [1] Chou TF, et al. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem. 2013 Feb;8(2):297-312.
- [2] Chou TF, et al. Selective, reversible inhibitors of the AAA ATPase p97. Probe Reports from the NIH Molecular Libraries Program. April 14, 2011.