[CAS NO. 2070015-26-6]  Sirtuinmodulator1

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PRODUCTS SPECIFICATIONS [2070015-26-6]

Catalog
HY-19758A
Brand
MCE
CAS
2070015-26-6

DESCRIPTION [2070015-26-6]

Overview

MDL-
Molecular Weight606.20
Molecular FormulaC31H32ClN5O2S2
SMILESO=C(C1=C(CCCOC)SC(C2=CC=CC=C2)=N1)NC3=CC=CC=C3C4=NC5=C(N=CC(CN6CCCC6)=C5)S4.Cl[H]

For research use only. We do not sell to patients.

Summary

Sirtuin modulator 1 is a modulator of SIRTl , a homolog of SIRT3 , with EC 1.5 of < 1 μM, extracted from patent WO 2010071853 A1, Compound No.4.


IC50 & Target

SIRT1

1 μM (EC1.5)


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 20.62 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6496 mL 8.2481 mL 16.4962 mL
5 mM 0.3299 mL 1.6496 mL 3.2992 mL
10 mM 0.1650 mL 0.8248 mL 1.6496 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 1.25 mg/mL (2.06 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (2.06 mM); Clear solution

* All of the co-solvents are available by MCE.