[CAS NO. 2070015-29-9] SJB3-019A
PRODUCTS SPECIFICATIONS [2070015-29-9]
DESCRIPTION [2070015-29-9]
Overview
| MDL | MFCD26960956 |
|---|---|
| Molecular Weight | 276.25 |
| Molecular Formula | C16H8N2O3 |
| SMILES | O=C1C2=C(OC(C3=CC=CN=C3)=N2)C(C4=CC=CC=C41)=O |
9 Publications Citing Use of MCE
- [1]Blood (2016) 128 (22): 3290.
- [2]Blood. 2015, 126 (23): 1813.
- [3]Mol Cell. 2020 Nov 19;80(4):633-647.e7.
- [4]Sci Adv. 2019 May 8;5(5):eaav3235.
- [5]Cell Chem Biol. 2021 Apr 27;S2451-9456(21)00213-0.
- [6]J Med Chem. 2022 Oct 11.
- [7]Biomedicines. 2020 Jun 4;8(6):152.
- [8]Int J Med Sci. 2021 Jan 1;18(1):245-255.
- [9]Harvard Medical School LINCS LIBRARY
Summary
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC 50 of 0.0781 μM.
IC50 & Target
IC50: 78.1 nM (ID1)
In Vitro
SJB3-019A (IC 50 =0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 10 mg/mL ( 36.20 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6199 mL | 18.0995 mL | 36.1991 mL |
| 5 mM | 0.7240 mL | 3.6199 mL | 7.2398 mL |
| 10 mM | 0.3620 mL | 1.8100 mL | 3.6199 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1 mg/mL (3.62 mM); Clear solution