[CAS NO. 20784-60-5] 4'-O-Methylbavachalcone

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PRODUCTS SPECIFICATIONS [20784-60-5]

Catalog

HY-N1910

Brand

MCE

CAS

20784-60-5

DESCRIPTION [20784-60-5]

Overview

MDL	MFCD02183383
Molecular Weight	338.40
Molecular Formula	C21H22O4
SMILES	O=C(C1=CC(C/C=C(C)\C)=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.

Summary

4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia , inhibits severe acute respiratory syndrome coronavirus ( SARS-CoV ) papain-like protease ( PLpro ) activity, with an IC ₅₀ of 10.1 μM ^[1] .

IC50 & Target

IC50: 10.1 μM (PLpro) ^[1]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 147.75 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9551 mL	14.7754 mL	29.5508 mL
5 mM	0.5910 mL	2.9551 mL	5.9102 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] 4'-O-Methylbavachalcone, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.

Synonyms

2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-

Chalcone, 2′,4-dihydroxy-4′-methoxy-5′-(3-methyl-2-butenyl)-

2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (E)-

(2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

4′-O-Methylbavachalcone

4′-O-Methylbroussochalcone B