[CAS NO. 2089293-61-6] NAcM-OPT
PRODUCTS SPECIFICATIONS [2089293-61-6]
DESCRIPTION [2089293-61-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 434.40 |
| Molecular Formula | C23H29Cl2N3O |
| SMILES | O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3 |
Summary
NAcM-OPT is an orally bioavailable cullin neddylation 1 ( DCN1 ) inhibitor, which potently inhibits the DCN1-UBE2M interaction [1] .
IC50 & Target
DCN1 [1]
In Vitro
NAcM-OPT (Compound 67) is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 287.75 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3020 mL | 11.5101 mL | 23.0203 mL |
| 5 mM | 0.4604 mL | 2.3020 mL | 4.6041 mL |
| 10 mM | 0.2302 mL | 1.1510 mL | 2.3020 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution