[CAS NO. 2094547-67-6] EN40
PRODUCTS SPECIFICATIONS [2094547-67-6]
DESCRIPTION [2094547-67-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 217.26 |
| Molecular Formula | C13H15NO2 |
| SMILES | C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O |
Summary
EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC 50 value of 2 uM [1]
IC50 & Target
IC50: 2 uM (ALDH3A1) [1]
In Vitro
EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | A549 cells |
| Concentration: | 10 μM; 100 μM; 1000 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited A549 cells survival. |
In Vivo
EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | SCID mice with A549 cells [1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 50mg/kg; from 14 days; once per day |
| Result: | Had strong anti-tumorigenic effects in tumor xenografts. |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 5 mg/mL ( 23.01 mM ; Need ultrasonic)
Ethanol : 2 mg/mL ( 9.21 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL |
| 5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL |
| 10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL |