[CAS NO. 2095484-82-3] (R)-eIF4A3-IN-2
PRODUCTS SPECIFICATIONS [2095484-82-3]
DESCRIPTION [2095484-82-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 602.70 |
| Molecular Formula | C25H19Br2ClN4O2 |
| SMILES | O=C(N1C[C@@H](C2=CC=C(Cl)C=C2)N(C(C3=CC=C(Br)C=C3)=O)CC1)C4=C5C=CC(Br)=CN5N=C4 |
Summary
(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC 50 of 110 nM [1] .
In Vitro
Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine triphosphate (ATP)-dependent RNA helicase [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 82.96 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6592 mL | 8.2960 mL | 16.5920 mL |
| 5 mM | 0.3318 mL | 1.6592 mL | 3.3184 mL |
| 10 mM | 0.1659 mL | 0.8296 mL | 1.6592 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution