[CAS NO. 2102681-49-0] SHMT-IN-2
PRODUCTS SPECIFICATIONS [2102681-49-0]
DESCRIPTION [2102681-49-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 431.45 |
| Molecular Formula | C22H24F3N5O |
| SMILES | NC1=C(C#N)C(C2=CC(N3CCCC3)=CC(C(F)(F)F)=C2)(C(C)C)C(C(C)=NN4)=C4O1 |
Summary
IC50 & Target
IC50: 2800 nM (SHMT1); IC50: 36 nM (SHMT2) [1]
In Vitro
SHMT-IN-2 (compound 2) can inhibit cell growth with cellular
IC
50
values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively
[1]
.
SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC
50
was 4 μM to a panel of nearly 300 human cancer cell lines (with IC
50
values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 231.78 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3178 mL | 11.5888 mL | 23.1777 mL |
| 5 mM | 0.4636 mL | 2.3178 mL | 4.6355 mL |
| 10 mM | 0.2318 mL | 1.1589 mL | 2.3178 mL |