[CAS NO. 2114651-20-4] β-Lactamase-IN-2

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PRODUCTS SPECIFICATIONS [2114651-20-4]

Catalog

HY-138247

Brand

MCE

CAS

2114651-20-4

DESCRIPTION [2114651-20-4]

Overview

MDL	-
Molecular Weight	208.19
Molecular Formula	C11H9FO3
SMILES	O=C(C1=C(OC=C2)C2=CC=C1F)OCC

For research use only. We do not sell to patients.

Summary

β-Lactamase-IN-2 is a beta-lactamase inhibitor, extracted from patent WO 2019075084 A1, compound 1. β-Lactamase-IN-2 has anti-microbial and anti-bacterial effects ^[1] .

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 480.33 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8033 mL	24.0165 mL	48.0330 mL
5 mM	0.9607 mL	4.8033 mL	9.6066 mL
10 mM	0.4803 mL	2.4017 mL	4.8033 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Scott J. Hecker, et al. Boronic acid derivatives and synthesis thereof. Patent WO 2019075084