[CAS NO. 211813-86-4] Eniporide hydrochloride
PRODUCTS SPECIFICATIONS [211813-86-4]
DESCRIPTION [211813-86-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 356.83 |
| Molecular Formula | C14H17ClN4O3S |
| SMILES | CS(=O)(C1=C(N2C=CC=C2)C=C(C)C(C(NC(N)=N)=O)=C1)=O.[H]Cl |
1 Publications Citing Use of MCE
Summary
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na + /H + exchange inhibitor.
IC50 & Target
Sodium Channel [1]
In Vitro
There is no significant effects of the Na + /H + exchange inhibitor eniporide on cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In stage 1, the administration of 100 mg and 150 mg eniporide results in smaller infarct sizes, especially in the angioplasty group. In contrast, in stage 2 there is no difference in the enzymatic infarct size between the three groups. Overall there is no effect of eniporide on clinical outcome (death, cardiogenic shock, heart failure, life-threatening arrhythmias). However, there is a significant reduction of the incidence of heart failure in patients reperfused late (>4 h) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 55 mg/mL ( 154.14 mM ; Need ultrasonic)
H 2 O : 4.17 mg/mL ( 11.69 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8025 mL | 14.0123 mL | 28.0245 mL |
| 5 mM | 0.5605 mL | 2.8025 mL | 5.6049 mL |
| 10 mM | 0.2802 mL | 1.4012 mL | 2.8025 mL |
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1.
Add each solvent one by one: PBS
Solubility: 3.33 mg/mL (9.33 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
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2.
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3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.75 mg/mL (7.71 mM); Clear solution
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4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.75 mg/mL (7.71 mM); Clear solution
References
- [1] Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77(2):658-63.
- [2] Zeymer U, et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50.