[CAS NO. 212844-54-7] PurvalanolB

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PRODUCTS SPECIFICATIONS [212844-54-7]

Catalog

HY-18299

Brand

MCE

CAS

212844-54-7

DESCRIPTION [212844-54-7]

Overview

MDL	-
Molecular Weight	432.90
Molecular Formula	C20H25ClN6O3
SMILES	O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Anticancer Drugs. 2022 Aug 9.

Summary

Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK , with IC ₅₀ s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B , CDK2-cyclin A , CDK2-cyclin E and CDK5-p35 , respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC ₅₀ >1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum ^[1] ^[1] .

IC50 & Target

cdc2/cyclin B

6 nM (IC ₅₀ )

cdk2/cyclin A

6 nM (IC ₅₀ )

CDK2/cyclinE

9 nM (IC ₅₀ )

CDK5/p35

6 nM (IC ₅₀ )

In Vitro

Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC ₅₀ of 7.07 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 40 mg/mL ( 92.40 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3100 mL	11.5500 mL	23.1000 mL
5 mM	0.4620 mL	2.3100 mL	4.6200 mL
10 mM	0.2310 mL	1.1550 mL	2.3100 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-

2-Chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]benzoic acid

Purvalanol B

NG 95