[CAS NO. 2133017-36-2]  GLP-26

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PRODUCTS SPECIFICATIONS [2133017-36-2]

Catalog
HY-124614
Brand
MCE
CAS
2133017-36-2

DESCRIPTION [2133017-36-2]

Overview

MDL-
Molecular Weight373.35
Molecular FormulaC19H17F2N3O3
SMILESO=C(C1=C(C)C(C(C(NCC#C)=O)=O)=C(C)N1C)NC2=CC=C(F)C(F)=C2

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system ( IC 50 =3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools [1] .


In Vitro

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type, with EC 50 values of 0.7 μM [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [2]

Cell Line: HepNTCP-DL cells
Concentration: 0.7-1.7 μM
Incubation Time: 3 days
Result: Reduced secreted HBeAg in HepNTCP-DL cells.

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 334.81 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6785 mL 13.3923 mL 26.7845 mL
5 mM 0.5357 mL 2.6785 mL 5.3569 mL
10 mM 0.2678 mL 1.3392 mL 2.6785 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.57 mM); Clear solution

* All of the co-solvents are available by MCE.